Endometrial Receptivity (UFA) Study – Recruitment Currently on Hold

Objective: To correlate the readiness of the uterus (expression of biomarkers) to pregnancy outcomes in natural and IVF cycles.

Participants trying to get pregnant naturally and through IVF will be asked to have a Uterine Fluid Aspiration (UFA) at different times of their cycles corresponding with their pre-receptive and receptive part of their menstrual cycle.

 

Frozen Embryo Transfer (FET) P6 vs. P7 study
Objective:
– To determine if frozen embryo transfer occurring on the sixth day or the seventh day of progesterone supplementation will lead to higher clinical pregnancy rates.
– To determine if frozen embryo transfer occurring on the sixth day or the seventh day of progesterone supplementation will lead to lower miscarriage rates.

Participants undergoing frozen embryo transfer will be randomized into two groups: P6 group will have frozen embryo transfer occur on the 6th day of progesterone treatment vs. P7 group will have embryo transfer performed on the 7th day of progesterone exposure.

IVF vs ICSI pilot survey study
Objective: to determine the future feasibility of performing a multi-centred, prospective, RCT in Canada of using ICSI versus conventional IVF for couples/patients with non-male factor infertility.

Participants undergoing their first IVF treatment will be asked to complete a short survey.

Dual Trigger Study
Objective: to evaluate whether the use of a “dual-trigger” (Superfact + Pregnyl) can improve IVF outcomes, compared to GnRH-a alone, in patients at high risk of OHSS undergoing a freeze-all cycle.

Participants who are considered at risk of developing OHSS and undergoing IVF treatment will be randomized into two groups: treatment arm (Superfact + Pregnyl) vs. control arm (Superfact + sham-placebo).

BRCA follicular fluid
Objective: to better understand conditions that contribute to the initiation of high-grade serous ovarian cancer to develop drugs or approaches to prevent the disease.

Participants have or will be tested for germline mutations in BRCA1 and BRCA2 will be asked to have their follicular fluid that’s normally discarded collected as part of the research.