PCOS UFA (uterine fluid aspiration) study
Currently on hold

Objective: to study the process of endometrial receptivity in participants with polycystic ovarian syndrome (PCOS).

Participants with PCOS will be monitored to check for signs of ovulation. Following confirmation of ovulation, UFA will be done at 2 different times.


ERA UFA (uterine fluid aspiration) study

Objective: to compare the endometrial receptivity assessment by ERA (Endometrial Receptivity Array) test and UFA in participants with recurrent implantation failure.

Participant who is willing to take ERA test will be asked to have UFA done at 2 different times.

Endometrial Receptivity (UFA) Study

Objective: To correlate the readiness of the uterus (expression of biomarkers) to pregnancy outcomes in natural and IVF cycles.

Participants trying to get pregnant naturally and through IVF will be asked to have a Uterine Fluid Aspiration (UFA) at different times of their cycles corresponding with their pre-receptive and receptive part of their menstrual cycle.


Administration of single high dose letrozole for ovulation induction – A randomized controlled trial

Objective:  to conduct a randomized controlled study comparing a single dose Letrozole (20 mg) on day 3 of the menstrual cycle to daily dose of Letrozole (2.5 mg) on days 3-7 of the menstrual cycle.

PCOS patients who require induction of ovulation will prospectively randomized into two groups: Single 20 mg dose of Letrozole on day 3 of the menstrual cycle vs. daily dose of Letrozole 2.5 mg starting day 3 for 5 days.


Elective Egg Freezing Needs Assessment for Decisional Support

Objective: to better qualify the need for development of a decision aid for patients considering social egg freezing, if it exists, in particular determining the areas in which patients and practitioners counselling patients feel decisional conflict and uncertainty, and the determinants of the decision of whether or not to pursue social egg freezing.

Participants will be asked to complete an interview either over the telephone or in-person.