Frozen Embryo Transfer (FET) P6 vs. P7 study
– To determine if frozen embryo transfer occurring on the sixth day or the seventh day of progesterone supplementation will lead to higher clinical pregnancy rates.
– To determine if frozen embryo transfer occurring on the sixth day or the seventh day of progesterone supplementation will lead to lower miscarriage rates.

Participants undergoing frozen embryo transfer will be randomized into two groups: P6 group will have frozen embryo transfer occur on the 6th day of progesterone treatment vs. P7 group will have embryo transfer performed on the 7th day of progesterone exposure.



IVF vs ICSI pilot survey study
Objective: to determine the future feasibility of performing a multi-centred, prospective, RCT in Canada of using ICSI versus conventional IVF for couples/patients with non-male factor infertility.

Participants undergoing their first IVF treatment will be asked to complete a short survey.



Dual Trigger Study
Objective: to evaluate whether the use of a “dual-trigger” (Superfact + Pregnyl) can improve IVF outcomes, compared to GnRH-a alone, in patients at high risk of OHSS undergoing a freeze-all cycle.

Participants who are considered at risk of developing OHSS and undergoing IVF treatment will be randomized into two groups: treatment arm (Superfact + Pregnyl) vs. control arm (Superfact + sham-placebo).



BRCA follicular fluid
Objective: to better understand conditions that contribute to the initiation of high-grade serous ovarian cancer to develop drugs or approaches to prevent the disease.

Breast cancer patients who have or will be tested for germline mutations in BRCA1 and BRCA2 will be asked to have their follicular fluid that’s normally discarded collected as part of the research.



Fit-for-fertility multicenter randomized-controlled trial: improving reproductive, maternal and neonatal outcomes in obese and infertile women
Objective: to evaluate the effectiveness of the Fit-for-Fertility Program on fertility and lifestyle outcomes in a diverse Canadian population.

Eligible obese patients will be assigned to either the intervention group or the control group. Participation involves 3 to 5 evaluation visits within a 18 month period at the clinic.

Intervention group: postpone any fertility treatment for 6 months to participate in the Fit-for-Fertility program where you will receive support from a nutritionist and a kinesiologist for a maximum of 18 months or the occurrence of ongoing pregnancy)

Control group: receive standard fertility treatment.



Elective egg freezing needs assessment for decisional support
Objective: to determine if development of a decision aid would help patients who have considered elective egg freezing with the decision-making process.

Participants will be asked to participate in a 20-min phone interview.